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M94A2899.TXT
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1994-10-25
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Document 2899
DOCN M94A2899
TI Effect of maternal HIV status on infant growth & survival.
DT 9412
AU Boulos R; Ruff A; Coberly J; McBrien M; Halsey JD; CDS, Port-au-Prince,
Haiti.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):20 (abstract no. 054B). Unique
Identifier : AIDSLINE ICA10/94369676
AB OBJECTIVE: Although growth failure and increased mortality are common
among HIV-infected infants, less is known about uninfected infants born
to HIV-1 seropositive women. This study was undertaken to compare the
growth and survival of breastfed infants born to HIV-1 seropositive and
seronegative women. METHODS: Growth parameters were available from 137
seropositive women and 270 seronegative women and their infants enrolled
and followed monthly for 18 months as part of a prospective study of
breastfeeding and HIV-1. Survival data were available for 191 infants
born to seropositive women and 290 infants born to seronegative women.
RESULTS: At 3 months of age, HIV-1 infected infants weighed
significantly less than infants born to seronegative women (5.54 vs 6.05
kg, p = 0.013) and these differences persisted through 18 months. At 18
months uninfected infants also had significantly lower weights and
heights than infants born to seronegative women. The survival rate at 18
months was 41% among HIV-1 infected infants, 84% among uninfected
infants born to seropositive women and 95% among infants born to
seronegative women. The risk ratio of death among uninfected infants
born to seropositive women was 3.20 (95% CD 1.61, 6.38) compared to
infants born to seronegative women. CONCLUSIONS: Uninfected infants born
to HIV-1 seropositive women exhibit poorer growth and survival than
infants born to seronegative women. Additional studies to determine the
etiology of these differences and to identify potential means of
intervention are underway.
DE Adult Body Weight Female Growth Human *HIV Seropositivity/MORTALITY
*HIV-1 Infant, Newborn/*PHYSIOLOGY Odds Ratio Pregnancy *Pregnancy
Complications, Infectious Prospective Studies MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).